Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Vosler, P.S.; Sun, D.; Wang, S.; Gao, Y.; Kintner, D.B.; Signore, A.P.; Cao, G.; Chen, J.
    Calcium dysregulation induces apoptosis-inducing factor release: cross-talk between PARP-1- and calpain-signaling pathways (2009), Exp. Neurol., 218, 213-220.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.52 calpastatin
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.52 Ca2+ calpain I is a calcium-dependent protease Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.52 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.52 cerebral cortical neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.52 apoptosis-inducing factor + H2O calpain-mediated truncation of apoptosis-inducing factor is contingent upon poly(ADP-ribose) polymerase-1 activity Rattus norvegicus ?
-
 ?
3.4.22.52 E-(EDANS)-PLFAERK-(Dabcyl) + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.52 calpain I
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.4.22.52 malfunction calpain inhibition prevents NMDA-induced AIF truncation and nuclear translocation in neurons Rattus norvegicus